Are there any adverse reactions to hyaluronic acid injections?

Hyaluronic acid injection is a very common cosmetic technique nowadays. Through micro-surgery, it is injected into the deepest layer of the skin, making the skin look younger, retaining moisture, reducing wrinkles, clearing melanin and achieving a whitening effect. However, some people may experience skin itching and allergic reactions such as urticaria after the injection due to certain physical conditions. Severe cases may even cause tumors. This is not allowed for some patients with heart failure or cancer, so special attention should be paid to it in normal times.

Adverse Reactions

In some cases, it may cause allergic reactions, including itching, urticaria and other more serious allergic reactions.

Taboo

1. Patients with malignant tumors are prohibited from using this product to prevent it from promoting the spread of tumors.

2. It is contraindicated for patients with heart failure or shock.

3. This product has the risk of causing the spread of infection and should not be injected into infected or inflamed areas or surrounding tissues. Use with caution if there is infection in other parts of the body.

Precautions

1. Do not use for intravenous injection.

2. Cannot be applied directly to the cornea.

3. It cannot be used for swelling caused by insect stings.

4. The aqueous solution is extremely unstable and should be prepared just before use. The remaining solution can be stored below 30°C for 2 weeks, but it cannot be used if there is discoloration or precipitation.

Pregnant and lactating women

1. The safety of the drug for pregnant women has not yet been confirmed. Do not use in pregnant women unless absolutely necessary.

2. It is not yet confirmed whether this product enters breast milk; nursing mothers should use it with caution.

Children's medication

This experiment has not been conducted and there are no reliable references.

Medication for the elderly

This experiment has not been conducted and there are no reliable references.

Drug interactions

1. Adding it to the anesthetic solution can accelerate the onset of anesthesia and reduce local swelling. At the same time, it also accelerates the absorption of local anesthetics, shortens the anesthesia time, and may cause unexpected systemic reactions.

2. When using this product in combination with other drugs, it should be considered that the absorption of the combined drugs is accelerated and the effects are enhanced.

3. Salicylate drugs can inhibit the diffusion of this product and should not be used at the same time.

Overdose

Excessive injection may cause local edema, allergic symptoms, erythema, nausea, vomiting, dizziness, rapid heartbeat and decreased blood pressure. The drug should be discontinued promptly and supportive treatment should be adopted. First aid can include epinephrine, corticosteroids and antihistamines.

Pharmacology and Toxicology

Hyaluronic acid is a mucopolysaccharide present in the matrix between human tissues, which can limit the diffusion of extracellular fluid. Hyaluronidase acts on the glucosamine bonds in hyaluronic acid molecules, causing them to hydrolyze and depolymerize, thereby reducing the viscosity of body fluids and allowing intercellular fluids to flow and diffuse more easily. Therefore, it can diffuse locally accumulated drug solutions, exudates or blood, accelerate drug absorption, reduce local tissue tension and pain, and facilitate the absorption and dissipation of edema and inflammatory exudates. This product is one of the basic components of articular cartilage and has the function of nourishing, protecting and maintaining articular cartilage.

Pharmacokinetics

This experiment has not been conducted and there are no reliable references.