What are the side effects of immunoadsorption therapy?

Some diseases are more complicated to treat, so a variety of treatment methods are needed. At present, immunoadsorption therapy is used to treat some diseases that are difficult to cure or when people have strong antibodies in their bodies. However, you can rest assured that this type of drug will basically not cause any drug resistance after use. However, as long as it is a treatment method, there will be some side effects. People can only pay more attention to adjustment after treatment to improve symptoms.

Immunoadsorption therapy is used for patients with high disease activity and high antibody titers in the body. It is generally safe to use in patients without contraindications. Transient hematuria may occur after surgery. This is just a physical process, so there is no so-called dependence.

Immunoadsorption (IA) therapy is a blood purification technology developed in the past 15 years. It combines highly specific antigens, antibodies or substances with specific physical and chemical affinity (ligands) with adsorption materials (carriers) to form adsorbents (columns), which selectively or specifically remove pathogenic factors in the blood, thereby purifying the blood and alleviating the condition. Immunoadsorption therapy is different from general non-specific blood perfusion. Immunoadsorption therapy is a new technology developed on the basis of plasma exchange. Its advantage is that it is more selective in removing pathogenic factors in plasma, with a smaller range and amount of loss of useful components in plasma, while avoiding various adverse effects caused by plasma transfusion.

1. Organ transplantation: Immunoadsorption therapy is used before transplantation for patients in a hypersensitive immune state, which can quickly eliminate HLA antibodies, turn cross-matching negative, and reduce the incidence of acute rejection reactions. After transplantation, when the graft function deteriorates and biopsy reveals acute rejection, the rejection reaction can be reversed by using enhanced immunoadsorption combined with anti-rejection drugs.

2. Crescentic nephritis: Immunoadsorption can effectively treat diseases such as Goodpasture's disease, Wegener's granulomatosis, polyarteritis nodosa, and lupus nephritis. By clearing autoantibodies and immune complexes, the patient's clinical symptoms and renal function are significantly improved.

3. Lipoprotein nephropathy: Through extracorporeal circulation and the use of immunoadsorption columns to remove abnormal lipoproteins in plasma, renal function can be restored to normal.

4. IgA nephropathy: Use the isolated and purified nephritis pathogenic substance IgA to immunize animals, separate and purify specific polyclonal antibodies from the antiserum, and prepare IgA nephropathy immunoadsorbent after immobilization. Specifically remove pathogenic substances IgA and immune complexes in the patient's blood to achieve the treatment goal.